![]() ![]() This makes the overall material more durable but still allows it to break apart or weaken when exposed to the right wavelength of light. Raman decided that instead of making a material composed exclusively of that light-sensitive polymer, she would use it to link together stronger components such as polyacrylamide. This polymer gel includes a chemical bond that is broken when exposed to a wavelength of light between 405 and 365 nanometers (blue to ultraviolet). To create the new material, Raman designed a light-sensitive hydrogel based on a material developed in the lab of Kristi Anseth, a former Langer lab postdoc who is now a professor of chemical and biological engineering at the University of Colorado at Boulder. ![]() ![]() Also, light normally does not penetrate the GI tract, so there is no chance of accidental triggering. One potential advantage is that light can act at a distance and doesn’t need to come into direct contact with the material being broken down. In this study, the researchers explored a light-based trigger, which they believed could offer some advantages over their earlier approaches. “We’re really looking at different triggers and how they perform, and whether we can apply them to different settings.” “Given our interests in developing systems that can reside for prolonged periods in the gastrointestinal tract, we continue to investigate a range of approaches to facilitate the removal of these systems in the setting of adverse reaction or when they are no longer needed,” Traverso says. They have also worked on a variety of strategies to control the breakdown of such devices, including methods based on changes in pH or temperature, or exposure to certain chemicals. ![]() Over the past several years, Traverso and Langer have developed many ingestible devices designed to remain in the GI tract for extended periods of time. Other authors of the paper are former technical associates Tiffany Hua, Jianlin Zhou, Tina Esfandiary, and Vance Soares technical associates Declan Gwynne, Joy Collins, and Siddartha Tamang graduate student Simo Pajovic Division of Comparative Medicine veterinarian Alison Hayward and David H. Ritu Raman, a postdoc at MIT’s Koch Institute for Integrative Cancer Research, is the lead author of the paper, which appears today in Science Advances. In a study in pigs, the researchers showed that devices made with this light-sensitive hydrogel can be triggered to break down after being exposed to blue or ultraviolet light from a small LED. “We are developing a set of systems that can reside in the gastrointestinal tract, and as part of that, we’re looking to develop different ways in which we can trigger the disassembly of devices in the GI tract without the requirement for a major procedure,” says Giovanni Traverso, an assistant professor of mechanical engineering, a gastroenterologist at Brigham and Women’s Hospital, and the senior author of the study. Incorporating this material into medical devices could avoid many endoscopic procedures and would give doctors a faster and easier way to remove devices when they are no longer needed or are not functioning properly, the researchers say. The new approach is based on a light-sensitive hydrogel that the researchers designed. However, MIT engineers have now come up with a way to trigger such devices to break down inside the body when they are exposed to light from an ingestible LED. Many of these have to be removed by endoscopic surgery once their job is done. We anticipate oral delivery of mRNA could facilitate rapid deployment of episodic interventions, such as vaccines, and support long-term therapies.A variety of medical devices can be inserted into the gastrointestinal tract to treat, diagnose, or monitor GI disorders. We validated the performance of formulations and devices in rodents and pigs, demonstrating protein translation in the delta, gastric, and parietal cells of the gastric mucosa, in addition to systemic uptake. To address these challenges, we synthesized and screened a library of branched hybrid poly(β-amino ester) mRNA nanoparticles for transfection efficiency then we combined the highest performing formulations with ingestible milli-injector capsules capable of delivering formulations directly into gastric tissue. Furthermore, oral delivery enables local transfection of cells in the gastrointestinal tract not easily targeted via parenteral administration. While these therapies have typically been limited to parenteral dosing, patients and clinicians prefer oral dosage forms. Nucleic acids are enabling a new generation of therapeutics and vaccines to treat and prevent a range of diseases. ![]()
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History 1995–2002: Beginnings as burlesque dance troupeĪntin began exploring the idea of a modern burlesque troupe during 1990 with Carla Kama and Christina Applegate as performers. 1.4 2017–2022: Reunion, tour and second disbandment.1.3 2008–2010: Doll Domination and disbandment.1.2 2003–2007: Recording group formation and PCD.1.1 1995–2002: Beginnings as burlesque dance troupe.In 2012, the Pussycat Dolls ranked 100th on VH1's 100 Greatest Women in Music, and as the tenth all-girl group. The group has sold 55 million records worldwide, making them one of the best-selling girl groups of all time. Billboard ranked the Pussycat Dolls as the 80th most successful musical act of the 2000s. ![]() The Pussycat Dolls brand diversified into merchandise, reality television programs, a Las Vegas act, product endorsements, spin-off recording groups ( Girlicious, Paradiso Girls, G.R.L.), and other ventures. 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The Pussycat Dolls achieved worldwide success with the singles " Don't Cha", " Stickwitu", " Buttons", and their multi-platinum debut album PCD (2005). Their debut single, " Sway", was featured on the soundtrack of the 2004 film Shall We Dance?. Antin negotiated a record deal with Interscope Geffen A&M Records in 2003 turning the group into a music franchise comprising Nicole Scherzinger, Carmit Bachar, Ashley Roberts, Jessica Sutta, Melody Thornton, and Kimberly Wyatt. At the suggestion of Jimmy Iovine, Antin decided to take the burlesque troupe mainstream as a pop group. The Pussycat Dolls were an American girl group and dance ensemble, founded in Los Angeles, California, by choreographer Robin Antin in 1995 as a burlesque troupe. ![]() ![]() If you notice a creature has for example 350/0 health, then you will need to make a medium stone (the blue one) put that stone in your hotbar to save his soul, and then kill him. 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So a creature that has weighted stats instead of evenly placed stats before taming could be potentially worse then a lower level creature with evenly placed stats. So you can theoretically tame a creature that has all stat points in HP, giving it a ridiculous amount of HP compared to a tame that has their stats spread more evenly. The game randomly allocates a creature's stat points, but you can find ones that have “weighted” stats. Also note that not all creature tames are created equal. That significantly increases the base amount of the stats, so when you add levels you can get a LOT more per point. So the higher level the tame, the more 'wild' and then 'bonus' levels the tame can spend. It's important to note that creature stats per leveling are a % base increase. Also, make sure not to punch, slice, or shoot magic at a taming creature, and use the fewest Hook arrows possible to keep it's constitution up. Items like the Rare Stone Hammer, which drops off Goblins and Goblin Elites, reduces their wildness substantially, so never use that for a good tame. ( Example: Wild Unicorn at level 110 fed with feed could tame out to 150 with a max level cap of 200.) ![]() 50 levels the tamed creature can go up with experience with a max (official) level of 200-215. Once you tame a creature there are approx. Protips: A maximum wild (official) creature is level 120, with proper feed to max out the creatures wildness (mechanic used to gain bonus levels) it can gain up to 45-50 bonus levels added to the base level of your targeted creature. For instance, when taming a Boar keep in mind that they have moderate base movement speed and can move and attack in short bursts with their charge attack. When you find your target animal for taking, consider the area you are in and the way the beast moves. Quantities and items vary per kill, there is also a chance instead of the item the blueprint would drop.When getting ready to tame you should first consider what type of beast you are aiming for, as there are restrictions to what can be tamed with Stone Hook Arrow versus Iron Hook Arrows. The following has a chance to drop once the creature is killed. ![]() ![]() ![]() Supports 3-digit hex colors too (#ABC meaning #AABBC)ĭevelopers: Added setWhenAdded to jAlbum's AlbumObject API JSpinner controls may now have Strings and Doubles too.įixed potential UI freeze when loading broken skinsįixed nullpointer exception during file copyingįixed bug stopping album making when errors in video processing occuredįixed bug causing cursor key navigation to fail when navigating objects of different heightĭeleted objects weren't put in the recycle bin when running on 64 bit Java engine Updated bundled Turtle, Base and Minimal skinsĭevelopers: New "videoPath" variable. 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(Install next to existing version to safely evaluate the improvements) JAlbum 13 comes with a new free 30 day trial for all users! Free update for all who have an active support & update plan. ![]() ![]() ![]() It’s very, very close to its inspiration. To be blunt, I’m not impressed by the house so I’m fine with having a dupe. I haven’t smelled the original, but I did try Whispers… and it was a headache/scrubber. I use BTP as a room spray and spray it on myself before bed. I will offer the dupe to my son or my niece. Their Thé Noir was too “clean”, so I ponied up for the real deal. I got dupes of Thé Noir 29, By The Fireplace, and Wood Sage and Sea Salt. Tl/dr: upvoting because discussion is important, but I had a different experience. Clearly the people who say they’ve ordered products and didn’t like them have “tried before they bashed” I say read the comments before you bash them. One woman’s cilantro is another woman’s soap, and all that. Some people like a perfume to last all day without reapplying. You know how sometimes you try a perfume and think Oh my god who would buy this crap? It smells like my couch after my dog has run in the rain and slept on it! and then you hear people saying that fragrance is their favorite? Just because you loved it doesn’t mean it’s for everyone. I’m not trying to be snarky but I just don’t understand your logic, I’m sorry. Yeah, I’m going to go with u/temporary_scientist4 on this one, that makes no sense at all. What? Because they were so happy to have found a fabulous dupe it made them angry they’d never have to buy the original again? Because they want everyone else to suffer and buy the originals instead of supporting Dossier to make sure it always exists so that people can get quality cheaper products? If anyone has had a good experience by all means, let me know.īought the original > had buyers remorse > decided to try the dupes > received and tried their orders > thought the dupes smelled exactly like the originals and vowed never to buy an original again > and gave their new-found amazing product… a terrible review? I think this company just manufactures cheap dupes that are drugstore quality and ups the hype with marketing and paying for negative reviews to be deleted. Victoria's Secret fragrances put these to shame! They're all just absolutely dreadful. Like the cheap bottles of crappy fragrance you see in check out lines at clothing stores like forever21 or old navy. There is nothing redeemingly earthy or warm about these, they smelled borderline green. I bought a majority of the "earthy warm" scents like woody oakmoss and woody sandalwood. Not the kind of nice clean bar soap, the kind of soap you mop floors with. ![]() I bought 5 bottles thinking I was getting fools gold but really it's just □Īll 5 bottles had a tinge of soapy smell to them. So, I'm here to WARN anyone who's thinking of ordering: stop. Sounds incredible, the website has great reviews and it's pretty much impossible to find any other reviews online? So I feel like everyone who's into fragrance wishes you could get all of your favorite frags at less than full price. ![]() ![]() ![]() It has very few requirements and is very easy to configure and install. It includes built-in pure PHP support for the IMAP and SMTP protocols, and all pages render in pure HTML 4.0 (with no JavaScript required) for maximum compatibility across browsers. SquirrelMail is a standards-based webmail package written in PHP4. accepts no responsibility for any damage caused by the use or misuse of this information.Ģ006-002: IMAP/SMTP Command Injection in SquirrelMail The information contained within this advisory is supplied "as-is" with no warranties or guarantees of fitness of use or otherwise. JanuQuick response, Version 5.1_2 was released. JanuThe vulnerability discovered by Internet Security Auditors ( JanuInitial vendor notification sent. January 13, 2006: Vendor response actualization. Jesús Olmos González (jolmos (at) isecauditors (dot) com). This vulnerability has been discovered and reported by This vulnerability affects the 123flaschat server up to 5.1 (released on Dec 22, 2005) The chat service can be crashed or compromissed remotelly. If the server is Windows, is it possible to get execution. Is it possible to hijack and modify the raw command, to inyect line feed (0x0a) or other characters to construct arbitrary content of the created/overwrited file. *Possible* remote execution if some config file is modified. ![]() It is possible to replace the existent files, to make a DoS, to erase logs, to create/change system accounts, to get other chat user/admin accounts or to make other effects in server's system. /./fcserver.sh try to replace the script. /././var/./././etc/groups/default.xml create an admin account by or other config settings. /./././var/log/messages if server run as root. /././etc/ssh/nf if server run as root. members/parker change parker's password, if now we login with parker user, he will be disconected. The username vector is WHERE, and WHAT can be: In the exploitation, there are two factors, WHERE and WHAT. This is dangerous becouse, a user can get others account, erase logs, modify the server's /etc/passwd or modify other config files. room_1.txtĮmail 128 yes field allow anybody to create a file in our system, with same priviledges as the server and almost arbitrary content. The user file has the following structure: size null parse example When a user creates an account, a file is created at members directory: /123flashchat/server/data/default/members/isec-user Username, password, repeat-password and email. The register form ask the following questions: The chat server has a user-register functionality, that can be enabled by the following sentence: Onīy default it is enabled and anybody can create a chat account. 2006-001: Arbitrary remote file creation in 123flashchat server.ġ23 Flash Chat is a full featured java chat server and flash chat client, the product homepage is and it is possible to test it at: ![]() ![]() ![]() Still, I wish Microsoft (and eBay) would be a little more proactive in dealing with scalpers, though. ![]() Give it a couple of years and I should be able to pick one up for significantly less than the MSRP, and proudly display it on my shelf. And if history has taught me anything, it’s that these consoles will eventually be sold on as gamers upgrade their systems. I certainly have no plans to spend $549/£479 on a Series X console when there is absolutely nothing wrong with mine. I would have liked to have had the Halo edition console, but the circumstances just aren’t there. I have an Xbox Series X and I’ll still be able to enjoy Halo Infinite in 4K HDR when it arrives on December 8. Head over to the Halo subreddit (opens in new tab) and you'll find a lot of people loudly complaining that Microsoft should have done something similar with the Halo infinite console. And eBay is pretty devoid of scalper listings, suggesting someone has actually done something about the sketchy world of console reselling. The Steam Deck pre-order system was not perfect, and you currently have to wait until Q2 2022 to get your hands on one, but you still can. And Steam Decks are still available to reserve. Valve managed to make the process of pre-ordering a Steam Deck a lot less painful by limiting the reservations of consoles to people with existing Steam IDs. That price was on an auction with six bids, and nearly seven days left to go.Ī lot of those listings seem to be shipping from Australia as well, which means you have to take shipping and potential customs or tax charges into account when you buy.Īnd we’ve already seen that it doesn’t have to be this way. In fact, at the time of writing, the cheapest price we saw on eBay was $750 (opens in new tab). And by friends, I mean the opposite.Ī quick look on eBay shows that there are already dozens of listings for the Halo Infinite Xbox Series X, with asking prices well over $1,000 (opens in new tab) in a lot of cases. Sadly, it turns out even those people struggled to fill their orders, thanks to our good old friends the scalpers. In other words, you had to have been watching Microsoft’s Gamescom presentation to be in with a chance of actually getting the console. My main issue now is that Microsoft has apparently learned absolutely nothing from the past year of trying to sell Xbox consoles.įor starters, Microsoft made the mistake of opening up pre-orders immediately after the console was announced, and naturally it sold out pretty much instantly. I feel a little bit embarrassed and foolish, though that's a first-world problem that doesn't really matter that much. The fact I jumped the gun and bought an Xbox Series X isn't the only reason I'm upset. Plus, even if Microsoft did release one, what were the odds that I was actually going to be able to buy one? Microsoft messed up as well So why would they divert precious resources to creating a special edition console with a fancy design? My logic was that Microsoft has had a nightmare of a time keeping the Xbox Series X in stock, especially with the global chip shortage. So after some speedy deliberation I decided to pull the trigger and do it. I never really tried to get a next-gen console, after seeing all the crushing disappointment from people that were. It was an exceptionally lucky find, especially since I hadn’t been keeping a close eye on Xbox Series X restocks. ![]() |
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